Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Hemophilia Prevalence Nearly Three Times Higher Than Previously Reported

Key clinical point: The number of people with hemophilia worldwide is higher than previously estimated, and patients still face a shortened life expectancy.

Major finding: The prevalence of hemophilia A is 17.1 cases per 100,000 males.

Study details: A meta-analysis of registry data from multiple countries concerning male patients with hemophilia A or B.

Disclosures: The study received no financial support. The investigators reported relationships with Pfizer, Roche, Novo Nordisk, and others.


Iorio A et al. Ann Intern Med. 2019 Sept 10. doi: 10.7326/M19-1208.