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Food allergy can be revealed in the epidermis of children with atopic dermatitis

Key clinical point: Children with both atopic dermatitis and food allergy can be distinguished from those with just atopic dermatitis via their nonlesional skin surface.

Major finding: Those in the AD FA+ group were found to have “a constellation of stratum corneum attributes,” including increased TEWL and lower levels of filaggrin gene breakdown products.

Study details: A prospective clinical study of 62 children aged 4-17 years who were divided into three groups: atopic dermatitis and food allergy, atopic dermatitis and no food allergy, and nonatopic controls.

Disclosures: The study was funded by the National Institute of Health/The National Institute of Allergy and Infectious Diseases’ Atopic Dermatitis Research Network, with partial support from the Edelstein Family Chair for Pediatric Allergy at NIH and a NIH/National Center for Advancing Translational Sciences Colorado Clinical and Translational Science Awards grant. Three of the authors declared being inventors of a patent that covers methods of identifying AD with FA as a unique endotype. No other conflicts of interest were reported.

Citation:

Leung DYM et al. Sci Transl Med. 2019 Feb 20. doi: 10.1126/scitranslmed.aav2685.