Clinical Edge

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Blood test might rival PET scan for brain amyloidosis

Key clinical point: A blood test that seems almost as good as amyloid PET scanning, the gold standard, for detecting asymptomatic amyloid plaques in the brain could be on the market in 2-3 years.

Major finding: The plasma ratio of amyloid-beta 42 peptide to amyloid-beta peptide 40 identified people who were PET positive and PET negative for amyloid with an area under the curve of 0.88 (95% confidence interval, 0.82-0.93).

Study details: The assay was tested in 158 people in their 60s and 70s.

Disclosures: The test is being commercialized by the lead investigator’s colleagues. She is not involved in the efforts.


Schindler S et al. Neurology. 2019 Oct 22;93(17):e1647-59.