Key clinical point: Markers of ovarian reserve dropped significantly from baseline for those taking a higher dose of isotretinoin for severe acne, as did anti-Müllerian hormone levels alone for those taking any dose of isotretinoin, but values rebounded for all after stopping treatment.
Major finding: For women taking isotretinoin 1 mg/kg/day, AMH levels went from 5.14 ng/mL at baseline to 4.24 ng/mL on treatment, to 4.65 ng/mL 1 month after treatment (P less than .001 for difference between baseline and on-drug values).
Study details: Prospective case-control study of 42 women of reproductive age prescribed isotretinoin for severe acne, and 26 women without acne.
Disclosures: Dr. Akbulut reported no outside sources of funding and that she had no relevant financial disclosures.
REPORTING FROM WCD2019