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Air Pollutants, Spontaneous Pregnancy Loss Linked

Fertil Steril; ePub 2018 Dec 4; Leiser, Hanson, et al

Short-term exposure to elevated levels of air pollutants was associated with higher risk for spontaneous pregnancy loss, according to a recent study. Researchers evaluated 1,398 women who experienced spontaneous pregnancy loss events at an academic emergency department in the Wasatch Front area of Utah. They found:

  • A 10-ppb increase in 7-day average levels of nitrogen dioxide was associated with a 16% increase in the odds of spontaneous pregnancy loss (odds ratio [OR]=1.16).
  • A 10-μg/m3 increase in 3-day and 7-day averages of fine particulate matter were associated with increased risk of spontaneous pregnancy loss, but the associations did not reach statistical significance (OR3-day average=1.09) (OR7-day average=1.11).
  • There was no evidence of increased risk for any other metrics of nitrogen dioxide or fine particulate matter or any metric for ozone.

Leiser CL, Hanson HA, Sawyer K, et al. Acute effects of air pollutants on spontaneous pregnancy loss: A case-crossover study. [Published online ahead of print December 4, 2018]. Fertil Steril. doi:10.1016/j.fertnstert.2018.10.028.