Clinical Edge

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Pro-inflammatory diets tied to osteoporosis risk

Key clinical point: Diets rich in pro-inflammatory components may increase the risk of osteoporosis, fractures, and lower bone mineral density (BMD) of lumbar spine and total hip.

Major finding: Dietary Inflammatory Index (DII) was negatively linked with BMD of lumbar spine (odds ratios [OR], 0.990; P = .144) and total hip (OR, 0.995; P = .392). The highest category of DII was associated with an elevated risk of osteoporosis (pooled effect size [ES], 1.31; 95% confidence interval [CI], 1.16-1.48) and fractures (pooled ES, 1.26; 95% CI, 1.03-1.59) compared with the lowest category of DII.

Study details: A meta-analysis of 11 studies (4 cohort, 1 case-control, and 6 cross-sectional) involving 127,769 participants.

Disclosures: The study was supported by the National Natural Science Foundation of China. The authors declared no conflicts of interest.


Fang Y et al. Osteoporos Int. 2020 Aug 1. doi: 10.1007/s00198-020-05578-8.