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Low Muscle Mass, Osteoporosis Linked in Women and Men

Key clinical point: Low muscle mass is associated with osteoporosis in both men and women for all age groups, excluding men aged 50-64 years.

Major finding: Low muscle mass was significantly associated with osteoporosis in the lumbar spine and femoral neck in women (lumbar spine: odds ratio, 1.52, 95% confidence interval, 1.17-1.97; femoral neck: OR, 2.09, 95% CI, 1.56-2.80) and men (lumbar spine: OR, 1.73; 95% CI, 1.08-2.76; femoral neck: OR, 3.39; 95% CI, 1.69-6.80).

Study details: Analysis of data for 14,429 participants aged 20 years or older (8,168 women, 6,261 men) from the 2009-2011 Korean National Health and Nutrition Examination Survey.

Disclosures: The authors reported no conflicts of interest.


"Prevalence of sarcopenia and osteoporosis increases with age. This study investigated the relationship between low muscle mass and osteoporosis in a large population-based community-dwelling cohort of Korean adults. Survey and health examination data from 8168 women with average age of 46 years and 6261 men with average age of 44 years were analyzed. After adjusting for important covariates including survey year, marital status, residence, waist circumference, lifestyle habits (e.g. smoking, alcohol use exercise), comorbidities, use of dietary supplements, and menopausal/past pregnancy status, low muscle mass was associated with osteoporosis in both men and women. In an age-stratified analysis (<50 years, 50-64 years, ≥ 65 years) the association between low bone mass and osteoporosis remained in all age categories, except for men aged 50-64 years. While this study does not imply causation given its cross-sectional design, the findings add to the body of literature aiming to clarify association between low muscle mass and osteoporosis."

Maria I. Danila, MD, MSc, MSPH
University of Alabama at Birmingham


Janga SY et al. Maturitas. 2020;133:54-9.