Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Diet and Reduction of Abdominal, Pericardial Fat

Obesity; ePub 2019 Mar 1; Hennein, Liu, McKeown, et al

Longitudinal improvements in diet quality are associated with less ectopic fat accumulation, according to a recent study. Therefore, diet quality may play a critical role in improving ectopic adiposity profiles. A total of 1,677 Framingham Heart Study participants who had ectopic fat depots measured using computed tomography were analyzed. Diet quality was quantified using a Mediterranean‐style diet score (MDS) and genetic risk by depot‐specific genetic risk scores (GRSs). Researchers found:

  • Per standard deviation (SD) improvement in MDS, there was 50 cm3 less fat accumulation in visceral adipose tissue (VAT), 52 cm3 less fat accumulation in subcutaneous adipose tissue (SAT), and 1.3 cm3 less fat accumulation in pericardial adipose tissue (PAT).
  • No association was observed between GRSs and ΔVAT or ΔSAT.
  • Each 1‐SD increase in the PAT GRS was associated with a 1.2‐cm3 increase in ΔPAT.
  • In participants with higher PAT GRS, those with ΔMDS ≥0 had a favorable change in PAT compared with the counterparts with ΔMDS <0.

Hennein R, Liu C, McKeown NM, et al. Increased diet quality is associated with long‐term reduction of abdominal and pericardial fat. [Published online ahead of print March 1, 2019]. Obesity. doi:10.1002/oby.22427.