Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Lifestyle Interventions Curb Gestational Weight Gain

Obesity; ePub 2018 Sep 6; Peaceman, Clifton, et al

Behavioral lifestyle interventions focusing primarily on diet and physical activity among women with overweight and obesity resulted in a significantly lower proportion of women with excess gestational weight gain (GWG), according to a recent study. Furthermore, this modest beneficial effect was consistent across diverse intervention modalities in a large, racially, and socioeconomically diverse US population of pregnant women. 7 clinical centers conducted separate randomized clinical trials to test different lifestyle intervention strategies to modify GWG in diverse populations. Eligibility criteria, specific outcome measures, and assessment procedures were standardized across trials. The results of the separate trials were combined using an individual‐participant data meta‐analysis. Researchers found:

  • For the 1,150 women randomized, the percent with excess GWG per week was significantly lower in the intervention group compared with the standard care group (61.8% vs 75.0%).
  • Total GWG from enrollment to 36 weeks' gestation was also lower in the intervention group (8.1 ± 5.2 vs 9.7 ± 5.4 kg; mean difference: −1.59 kg).
  • The results from the individual trials were similar.
  • The intervention and standard care groups did not differ in preeclampsia, gestational diabetes, cesarean delivery, or birth weight.
Citation:

Peaceman AM, Clifton RG, Phelan S, et al. Lifestyle interventions limit gestational weight gain in women with overweight or obesity: LIFE‐Moms prospective meta‐analysis. [Published online ahead of print September 6, 2018]. Obesity. doi:10.1002/oby.22250.

This Week's Must Reads

National Trends: Thyrotoxicosis and Thyroid Storm, Thyroid; ePub 2018 Dec 18; Galindo, Hurtado, et al

Pancreas Volume is Decreased After T1D Onset, Diabetes Care; ePub 2018 Dec 14; Virostko, et al

PCOS Phenotype in Adolescence Not Linked to BMI, Fertil Steril; ePub 2018 Dec 6; Zore, Lizneva, et al

Air Pollutants, Spontaneous Pregnancy Loss Linked, Fertil Steril; ePub 2018 Dec 4; Leiser, Hanson, et al

Proinsulin Secretion Persistent in Type 1 Diabetes, Diabetes Care; ePub 2018 Dec 10; Sims, et al

Must Reads in Obesity

Central Obesity Increases Gestational Diabetes Risk, Obesity; ePub 2018 Nov 21; Zhu, et al

BMI a Risk Factor for T2D Regardless of HDP History, Diabetes Care; ePub 2018 Nov 19; Timpka, et al

Heavy Drinkers at Risk for Suboptimal Weight Loss, Obesity; ePub 2018 Nov 13; Chao, Wadden, et al

Modifiable Lifestyle Behaviors May Improve MetS, J Clin Endocrinol Metab; ePub 2018 Oct 25; Ward, et al

Hypothalamic Obesity Treatment Strategies Explored, Obesity; ePub 2018 Oct 8; Rose, Horne, et al