Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Depression in Women with PCOS Assessed

Fertil Steril; ePub 2018 Nov 17; Greenwood, et al

The prevalence of depression was relatively stable over time in a cohort of women with polycystic ovary syndrome (PCOS), according to a recent prospective cohort study. An elevated body mass index (BMI), however, is a hallmark of enduring depression risk. These results may assist providers in developing targeted intervention strategies to reduce the prevalence of long-term depressive symptoms in women with PCOS. The Beck Depression Inventory (BDI) Fast Screen (BDI-FS) was self-administered to 163 women with PCOS at baseline and follow-up to identify depression risk, using a cutoff score >4. Researchers found:

  • 59 of 163 women had positive depression screens at baseline (36%); 52 women (32%) screened positive at follow-up.
  • Of the 59 women at risk for depression at baseline, 22 screened negative at follow-up (37%), while 37 women remained at risk (63%).
  • Considering these 59 women with positive depression screens at baseline, higher BMI was associated with increased odds of enduring depression risk at follow-up in a multivariate logistic regression model.
  • Compared with women with normal body weight at baseline, obese women (BMI >30 kg/m2) had 5-fold increased odds of enduring depression risk at follow-up.


Greenwood EA, Pasch LA, Shinkai K, Cedars MI, Huddleston HG. Clinical course of depression symptoms and predictors of enduring depression risk in women with polycystic ovary syndrome: Results of a longitudinal study. [Published online ahead of print November 17, 2018]. Fertil Steril. doi:10.1016/j.fertnstert.2018.10.004.

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