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Men with Anorexia Nervosa at Risk for Low BMD

Clin Endocrinol; ePub 2019 Feb 28; Schorr, et al

Men with anorexia nervosa (AN), avoidant/restrictive food intake disorder (ARFID), and atypical AN (ATYP) (AN psychological symptoms without low weight) are at risk for low bone mineral density (BMD), according to a recent study. Men with these eating disorders who are low weight, or who have low muscle mass, long illness duration, and/or vitamin D deficiency, may be at particularly high risk. Participants included 103 men, aged 18‐63 years: AN (n=26), ARFID (n=11), ATYP (n=18), and healthy controls (HC) (n=48). Researchers evaluated body composition, BMD, and estimated hip strength (section modulus and buckling ratio) by DXA. Serum 25OH vitamin D was quantified, as was daily calcium intake in a subset of subjects. They found:

  • Mean BMI was lowest in AN and ARFID, higher in ATYP, and highest in HC (AN 14.7±1.8, ARFID 15.3±1.5, ATYP 20.6±2.0, HC 23.7±3.3 kg/m2).
  • Mean BMD Z‐scores at spine and hip were lower in AN and ARFID, but not ATYP, than HC (PA spine AN ‐2.05±1.58, ARFID ‐1.33±1.21, ATYP ‐0.59±1.77, HC ‐0.12±1.17).
  • 65% AN, 18% ARFID, 33% ATYP, and 6% HC had BMD Z‐scores <‐2 at ≥1 site (AN and ATYP vs HC).
Citation:

Schorr M, Drabkin A, Rothman MS, et al. Bone mineral density and estimated hip strength in men with anorexia nervosa, atypical anorexia nervosa and avoidant/restrictive food intake disorder. [Published online ahead of print February 28, 2019]. Clin Endocrinol. doi:10.1111/cen.13960.