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Men with Anorexia Nervosa at Risk for Low BMD

Clin Endocrinol; ePub 2019 Feb 28; Schorr, et al

Men with anorexia nervosa (AN), avoidant/restrictive food intake disorder (ARFID), and atypical AN (ATYP) (AN psychological symptoms without low weight) are at risk for low bone mineral density (BMD), according to a recent study. Men with these eating disorders who are low weight, or who have low muscle mass, long illness duration, and/or vitamin D deficiency, may be at particularly high risk. Participants included 103 men, aged 18‐63 years: AN (n=26), ARFID (n=11), ATYP (n=18), and healthy controls (HC) (n=48). Researchers evaluated body composition, BMD, and estimated hip strength (section modulus and buckling ratio) by DXA. Serum 25OH vitamin D was quantified, as was daily calcium intake in a subset of subjects. They found:

  • Mean BMI was lowest in AN and ARFID, higher in ATYP, and highest in HC (AN 14.7±1.8, ARFID 15.3±1.5, ATYP 20.6±2.0, HC 23.7±3.3 kg/m2).
  • Mean BMD Z‐scores at spine and hip were lower in AN and ARFID, but not ATYP, than HC (PA spine AN ‐2.05±1.58, ARFID ‐1.33±1.21, ATYP ‐0.59±1.77, HC ‐0.12±1.17).
  • 65% AN, 18% ARFID, 33% ATYP, and 6% HC had BMD Z‐scores <‐2 at ≥1 site (AN and ATYP vs HC).

Schorr M, Drabkin A, Rothman MS, et al. Bone mineral density and estimated hip strength in men with anorexia nervosa, atypical anorexia nervosa and avoidant/restrictive food intake disorder. [Published online ahead of print February 28, 2019]. Clin Endocrinol. doi:10.1111/cen.13960.