Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Poor Sleep Quality Linked with Insulin Resistance

Metab Syndr Relat Disord; ePub 2018 Mar 20; Kline, et al

Sleep quality is an important correlate of insulin resistance in postmenopausal women with and without metabolic syndrome (MetS), according to a recent study. Participants included 347 overweight/obese postmenopausal women without type 2 diabetes (age: 57.5 ± 6.5 years; body mass index [BMI]: 31.7 ± 3.7 kg/m2; 54% with MetS). Sleep quality was assessed with the 6-item Medical Outcomes Study Sleep Scale; values were categorized into quartiles. Insulin resistance was calculated from fasting glucose and insulin with the homeostasis model assessment of insulin resistance (HOMA2-IR) method. Researchers found:

  • Women with the worst sleep quality had significantly higher HOMA2-IR values than women in all other quartiles, and women with MetS had significantly higher HOMA2-IR values than women without MetS, but the relationship between sleep quality and HOMA2-IR did not differ between those with or without MetS.
  • Women with MetS in the worst quartile of sleep quality had higher HOMA2-IR values than all other women.
  • Taking >30 minutes to fall asleep, frequent restless sleep, and frequent daytime drowsiness were each related to higher HOMA2-IR values.

Citation:

Kline CE, Hall MH, Buysse DJ, Earnest CP, Church TS. Poor sleep quality is associated with insulin resistance in postmenopausal women with and without metabolic syndrome. [Published online ahead of print March 20, 2018]. Metab Syndr Relat Disord. doi:10.1089/met.2018.0013.

This Week's Must Reads

Diabetic kidney disease, retinopathy associated with PAD in patients with foot ulcers, Megallaa MH et al. Diabetes Metab Syndr. 2019 Mar-Apr;13(2):1287-92.

Eye Exam Visits Low Among People with Diabetes, Diabetes Care; ePub 2019 Jan 24; Benoit, et al

Glycemic Variability and Risk of CV Events Assessed, Diabetes Care; ePub 2019 Jan 18; Echouffo-Tcheugui, et al

Insomnia Associated with Increased Risk of T2D, BMJ Open Diabetes Res Care; 2018 Dec; LeBlanc, et al

Class III/IV Obesity and Oocyte Retrieval Examined, Fertil Steril; 2019 Feb; Romanski, Farland, et al

Must Reads in Menopause

Anthropometric Measures as Diabetes Risk Factors, Diabetes Care; ePub 2018 Oct 23; Luo, Hendryx, et al

Markers of Bone Turnover, Diabetes Examined, Diabetes Care; ePub 2018 Jul 12; Massera, et al

Poor Sleep Quality Linked with Insulin Resistance, Metab Syndr Relat Disord; ePub 2018 Mar 20; Kline, et al

Menopausal Hormone Therapy and Mortality Evaluated, JAMA; 2017 Sep 12; Manson, Aragaki, et al

Updated AACE/ACE Guideline on Menopause , Endocr Pract; 2017 Jul 12; Cobin, Goodman