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Modifiable Lifestyle Behaviors May Improve MetS

J Clin Endocrinol Metab; ePub 2018 Oct 25; Ward, et al

Modifiable lifestyle behaviors were related to recovery from metabolic syndrome (MetS) and decreased risk of the most frequent MetS constellations in midlife women, a recent study found. Researchers conducted a prospective longitudinal, multi-ethnic cohort study of 3,003 midlife women at 7 US sites undergoing the menopausal transition (MT). MetS meant having at least 3 of 5 components: high fasting triglyceride (hTG), low high density lipoprotein cholesterol (lHDL), high fasting plasma glucose (hGluc), large waist circumference (Ob), and hypertension (HTN). They found:

  • Breakdown of participants by race/ethnicity included 1,412 non-Hispanic white, 851 black, 272 Japanese, 237 Hispanic, and 231 Chinese women.
  • Central obesity was the most frequent component.
  • Having no components was the most frequent (31%) baseline constellation.
  • Physical activity (HR = 1.68) and lower caloric intake (HR = 0.96; per 100 cal/day) were associated with recovery from MetS.
  • Ob/hTG/lHDL (18%), Ob/HTN/lHDL (16%), and Ob/HTN/hGluc (14%) were frequent incident constellations.
  • Physically active women had 26-62% lower hazards of incident MetS than inactive women.

Ward E, Gold EB, Johnson WO, et al. Patterns of cardiometabolic health as midlife women transition to menopause: A prospective multi-ethnic study. [Published online ahead of print October 25, 2018]. J Clin Endocrinol Metab. doi:10.1210/jc.2018-00941.