Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Modifiable Lifestyle Behaviors May Improve MetS

J Clin Endocrinol Metab; ePub 2018 Oct 25; Ward, et al

Modifiable lifestyle behaviors were related to recovery from metabolic syndrome (MetS) and decreased risk of the most frequent MetS constellations in midlife women, a recent study found. Researchers conducted a prospective longitudinal, multi-ethnic cohort study of 3,003 midlife women at 7 US sites undergoing the menopausal transition (MT). MetS meant having at least 3 of 5 components: high fasting triglyceride (hTG), low high density lipoprotein cholesterol (lHDL), high fasting plasma glucose (hGluc), large waist circumference (Ob), and hypertension (HTN). They found:

  • Breakdown of participants by race/ethnicity included 1,412 non-Hispanic white, 851 black, 272 Japanese, 237 Hispanic, and 231 Chinese women.
  • Central obesity was the most frequent component.
  • Having no components was the most frequent (31%) baseline constellation.
  • Physical activity (HR = 1.68) and lower caloric intake (HR = 0.96; per 100 cal/day) were associated with recovery from MetS.
  • Ob/hTG/lHDL (18%), Ob/HTN/lHDL (16%), and Ob/HTN/hGluc (14%) were frequent incident constellations.
  • Physically active women had 26-62% lower hazards of incident MetS than inactive women.

Ward E, Gold EB, Johnson WO, et al. Patterns of cardiometabolic health as midlife women transition to menopause: A prospective multi-ethnic study. [Published online ahead of print October 25, 2018]. J Clin Endocrinol Metab. doi:10.1210/jc.2018-00941.

This Week's Must Reads

Diabetic kidney disease, retinopathy associated with PAD in patients with foot ulcers, Megallaa MH et al. Diabetes Metab Syndr. 2019 Mar-Apr;13(2):1287-92.

Eye Exam Visits Low Among People with Diabetes, Diabetes Care; ePub 2019 Jan 24; Benoit, et al

Glycemic Variability and Risk of CV Events Assessed, Diabetes Care; ePub 2019 Jan 18; Echouffo-Tcheugui, et al

Insomnia Associated with Increased Risk of T2D, BMJ Open Diabetes Res Care; 2018 Dec; LeBlanc, et al

Class III/IV Obesity and Oocyte Retrieval Examined, Fertil Steril; 2019 Feb; Romanski, Farland, et al

Must Reads in Hypertension

Metabolic Health in Americans Alarmingly Low, Metab Syndr Relat Disord; ePub 2018 Nov 27; Araújo, et al

BMI a Risk Factor for T2D Regardless of HDP History, Diabetes Care; ePub 2018 Nov 19; Timpka, et al

Modifiable Lifestyle Behaviors May Improve MetS, J Clin Endocrinol Metab; ePub 2018 Oct 25; Ward, et al

BP Treatment Assessed Among Persons with Diabetes, Diabetes Care; ePub 2018 Aug 27; Muntner, et al

ADA Position Statement on Diabetes, Hypertension, Diabetes Care; 2017 Sep; de Boer, et al