Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Bisphosphonates Improve BMD in Pediatric Rheumatic Disease

Key clinical point: Bisphosphonate therapy can improve BMD in pediatric rheumatic patients on steroids.

Major finding: Risedronate achieved greater BMD gains, compared with alfacalcidol or placebo.

Study details: Double-blind, randomized placebo-controlled trial in 217 patients on steroids for chronic rheumatic disease.

Disclosures: Arthritis Research UK funded the study. No conflicts of interest were declared.


Rooney M et al. EClinicalMedicine. 2019 Jul 3. doi: 10.1016/j.eclinm.2019.06.004.