Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Vitamin D did not reduce progression to type 2 diabetes

Key clinical point: Vitamin D supplementation did significantly lower the risk of diabetes.

Major finding: Progression to diabetes occurred in 293 on vitamin D and 323 on placebo.

Study details: Randomized placebo controlled trial of 2,423 patients with prediabetes.

Disclosures: The study was funded by the NIDDK, NIH Office of Dietary Supplements, and American Diabetes Association. Dr. Pittas reports grants from the same institutions during the conduct of the study. Many coauthors disclosed relationships with multiple drug companies.


Pittas AG et al. ADA 2019