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Quality of Life and T2D in Women Examined

Diabet Med; ePub 2018 Dec 15; Danhauer, et al

In order to improve health behaviors and quality of life (QOL) in women with type 2 diabetes (T2D), sociodemographic and medical characteristics may identify at‐risk populations, while psychosocial factors, including depression and optimism, may be important targets for non‐pharmacological intervention. Participants in the Women's Health Initiative with T2D and data on depressive symptoms (n=8,895) were included in the analyses. In multivariable linear regression models controlling for sociodemographic, medical, and psychosocial covariates, researchers examined the main effect of depressive symptoms, as well as the interactions between depressive symptoms and antidepressant use, and between depressive symptoms and optimism, on sleep disturbance, physical activity, physical health‐related (hrQOL), and global QOL. They found:

  • In all, 16% of women with T2D reported elevated depressive symptoms.
  • In multivariable analyses, women with depressive symptoms had greater sleep disturbance and lower global QOL.
  • There was evidence of significant statistical interaction in the models for QOL outcomes: The increased risk of poor physical hrQOL associated with antidepressant use was stronger in women without vs with depressive symptoms, and the association between greater optimism and higher global QOL was stronger in women with vs without depressive symptoms.

Danhauer SC, Brenes GA, Levine BJ, et al. Variability in sleep disturbance, physical activity and quality of life according to level of depressive symptoms in women with type 2 diabetes. [Published online ahead of print December 15, 2018]. Diabet Med. doi:10.1111/dme.13878.