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Markers of Bone Turnover, Diabetes Examined

Diabetes Care; ePub 2018 Jul 12; Massera, et al

In late postmenopausal women, levels of lower osteocalcin (OC), a marker of bone formation, and C-telopeptide of type 1 collagen (CTX), a marker of bone resorption, were associated with similarly increased risks of insulin resistance (HOMA-IR) at baseline and incident diabetes over long-term follow-up. This according to a recent study that sought to investigate the relationship between OC and CTX with incident diabetes in older women. The analysis included 1,455 female participants from the population-based Cardiovascular Health Study (mean [SD] age 74.6 [5.0] years). Researchers found:

  • OC and CTX were strongly correlated (r=0.80).
  • In cross-sectional analyses, significant or near-significant inverse associations with HOMA-IR were observed for continuous levels of OC (β=−0.12 per SD increment) and CTX (β=−0.08 per SD) after full adjustment for demographic, lifestyle, and clinical covariates.
  • During a median follow-up of 11.5 years, 196 cases of incident diabetes occurred.
  • After full adjustment, both biomarkers exhibited inverse associations with incident diabetes, associations that were comparable in magnitude and approached or achieved statistical significance.


Massera D, Biggs ML, Walker MD, et al. Biochemical markers of bone turnover and risk of incident diabetes in older women: The Cardiovascular Health Study. [Published online ahead of print July 12, 2018]. Diabetes Care. doi:10.2337/dc18-0849.