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Markers of Bone Turnover, Diabetes Examined

Diabetes Care; ePub 2018 Jul 12; Massera, et al

In late postmenopausal women, levels of lower osteocalcin (OC), a marker of bone formation, and C-telopeptide of type 1 collagen (CTX), a marker of bone resorption, were associated with similarly increased risks of insulin resistance (HOMA-IR) at baseline and incident diabetes over long-term follow-up. This according to a recent study that sought to investigate the relationship between OC and CTX with incident diabetes in older women. The analysis included 1,455 female participants from the population-based Cardiovascular Health Study (mean [SD] age 74.6 [5.0] years). Researchers found:

  • OC and CTX were strongly correlated (r=0.80).
  • In cross-sectional analyses, significant or near-significant inverse associations with HOMA-IR were observed for continuous levels of OC (β=−0.12 per SD increment) and CTX (β=−0.08 per SD) after full adjustment for demographic, lifestyle, and clinical covariates.
  • During a median follow-up of 11.5 years, 196 cases of incident diabetes occurred.
  • After full adjustment, both biomarkers exhibited inverse associations with incident diabetes, associations that were comparable in magnitude and approached or achieved statistical significance.

Citation:

Massera D, Biggs ML, Walker MD, et al. Biochemical markers of bone turnover and risk of incident diabetes in older women: The Cardiovascular Health Study. [Published online ahead of print July 12, 2018]. Diabetes Care. doi:10.2337/dc18-0849.

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