Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Markers of Bone Turnover, Diabetes Examined

Diabetes Care; ePub 2018 Jul 12; Massera, et al

In late postmenopausal women, levels of lower osteocalcin (OC), a marker of bone formation, and C-telopeptide of type 1 collagen (CTX), a marker of bone resorption, were associated with similarly increased risks of insulin resistance (HOMA-IR) at baseline and incident diabetes over long-term follow-up. This according to a recent study that sought to investigate the relationship between OC and CTX with incident diabetes in older women. The analysis included 1,455 female participants from the population-based Cardiovascular Health Study (mean [SD] age 74.6 [5.0] years). Researchers found:

  • OC and CTX were strongly correlated (r=0.80).
  • In cross-sectional analyses, significant or near-significant inverse associations with HOMA-IR were observed for continuous levels of OC (β=−0.12 per SD increment) and CTX (β=−0.08 per SD) after full adjustment for demographic, lifestyle, and clinical covariates.
  • During a median follow-up of 11.5 years, 196 cases of incident diabetes occurred.
  • After full adjustment, both biomarkers exhibited inverse associations with incident diabetes, associations that were comparable in magnitude and approached or achieved statistical significance.

Citation:

Massera D, Biggs ML, Walker MD, et al. Biochemical markers of bone turnover and risk of incident diabetes in older women: The Cardiovascular Health Study. [Published online ahead of print July 12, 2018]. Diabetes Care. doi:10.2337/dc18-0849.

This Week's Must Reads

National Trends: Thyrotoxicosis and Thyroid Storm, Thyroid; ePub 2018 Dec 18; Galindo, Hurtado, et al

Pancreas Volume is Decreased After T1D Onset, Diabetes Care; ePub 2018 Dec 14; Virostko, et al

PCOS Phenotype in Adolescence Not Linked to BMI, Fertil Steril; ePub 2018 Dec 6; Zore, Lizneva, et al

Air Pollutants, Spontaneous Pregnancy Loss Linked, Fertil Steril; ePub 2018 Dec 4; Leiser, Hanson, et al

Proinsulin Secretion Persistent in Type 1 Diabetes, Diabetes Care; ePub 2018 Dec 10; Sims, et al

Must Reads in Diabetes

Pancreas Volume is Decreased After T1D Onset, Diabetes Care; ePub 2018 Dec 14; Virostko, et al

Proinsulin Secretion Persistent in Type 1 Diabetes, Diabetes Care; ePub 2018 Dec 10; Sims, et al

Cerebrovascular Origin for Depression in T1D?, Diabet Med; ePub 2018 Dec 15; Nunley, et al

Quality of Life and T2D in Women Examined, Diabet Med; ePub 2018 Dec 15; Danhauer, et al

Cost-Related Insulin Underuse Evaluated, JAMA Intern Med; ePub 2018 Dec 3; Herkert, et al