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Insomnia Associated with Increased Risk of T2D

BMJ Open Diabetes Res Care; 2018 Dec; LeBlanc, et al

Insomnia imparts an increased risk of type 2 diabetes (T2D) comparable with that conferred by traditional risk factors (eg, overweight, non-white race, cardiovascular risk factors), according to a recent study. Researchers conducted a retrospective cohort study to examine the risk of developing T2D among patients with pre-diabetes with and without insomnia. Participants diagnosed with pre-diabetes between January 1, 2007, and December 31, 2015, and without sleep apnea were followed until December 31, 2016. Patients were determined to have T2D when 2 of the following occurred within a 2-year window: physician-entered outpatient T2D diagnosis, dispensing of an antihyperglycemia agent, and hemoglobin A1c (A1c) >6.5% (48 mmol/mol) or fasting plasma glucose (FPG) >125 mg/dL. 1 hospital inpatient stay with an associated T2D diagnosis was also sufficient for classification of T2D. Highlights included:

  • The cohort consisted of 81,233 persons with pre-diabetes, 24,146 (29.7%) of whom had insomnia at some point during the 4.3-year average observation period.
  • After adjustment for traditional risk factors, those with insomnia were 28% more likely to develop T2D than those without insomnia.
  • The estimate was essentially unchanged after adjusting for baseline A1c level or FPG.


LeBlanc E, Smith NX, Nichols GA, Allison MJ, Clarke GN. Insomnia is associated with an increased risk of type 2 diabetes in the clinical setting. BMJ Open Diabetes Res Care. 2018;6(1):e000604. doi:10.1136/bmjdrc-2018-000604.