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High Plasma Glucose in Apparently Healthy People

Diabetes Vasc Dis; ePub 2019 Feb 13; Abbasi, et al

Plasma glucose concentration of 8.6 mmol/L 60-minute post-oral glucose identifies higher proportions of combined impaired fasting glucose and impaired glucose tolerance individuals as well as normal glucose tolerance and impaired fasting glucose individuals with a more adverse cardio-metabolic profile, according to a recent study. Furthermore, this contributed to an observed increase in overall risk of type 2 diabetes and other metabolic diseases. Researchers conducted a comparison of resistance to insulin action and associated cardio-metabolic risk factors in 490 apparently healthy persons, subdivided into those with a plasma glucose concentration 60 minutes following a 75-g oral glucose challenge of <8.6 vs ≥8.6. They found:

  • Insulin resistance was significantly greater in persons with normal glucose tolerance whose 60-minute glucose concentration was 8.6, associated with higher blood pressure, plasma concentrations of glucose, insulin, triglyceride, and lower high-density lipoprotein cholesterol concentrations.
  • The group whose 60-minute glucose was <8.6 (n=318) contained primarily persons with normal glucose tolerance (88%), whereas the majority of those whose 60-minute value was 8.6 (n=172) had prediabetes (59%) and in particular combined impaired fasting glucose and impaired glucose tolerance.

Abbasi F, Tern PJW, Reaven GM. Plasma glucose concentration 60 min post oral glucose load and risk of type 2 diabetes and cardiovascular disease: Pathophysiological implications. [Published online ahead of print February 13, 2019]. Diabetes Vasc Dis. doi:10.1177%2F1479164119827239.