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Gestational Diabetes and Renal Function Examined

Diabetes Care; ePub 2018 May 4; Rawal, et al

Women who develop gestational diabetes mellitus (GDM) in pregnancy were more likely to show increased estimated glomerular filtration rate (eGFR) levels at 9-16 years’ postpartum, which could indicate early stages of glomerular hyperfiltration and renal damage, according to a recent study. However, only those who subsequently developed diabetes showed overt renal damage as evidenced by elevated urinary albumin-to-creatinine ratio (UACR). In the Diabetes & Women’s Health (DWH) study (2012–2016), researchers examined the independent and joint associations of GDM and subsequent diabetes with long-term renal function among 607 women with and 619 women without GDM. At median follow-up of 13 years after the index pregnancy, serum creatinine (mg/dL), and urinary albumin (mg/L) and creatinine (mg/dL) were measured, from which eGFR (mL/min/1.73 m2) and UACR (mg/g) were derived. They found:

  • Compared with women without GDM or subsequent diabetes, women with a GDM history had significantly higher eGFR even if they had not subsequently developed diabetes.
  • Women who had a GDM history and later developed diabetes (n=183) also had significantly higher UACR and an increased risk of elevated UACR (≥20 mg/g) compared with women with neither.
Citation:

Rawal S, Olsen SF, Grummet LG, et al. Gestational diabetes mellitus and renal function: A prospective study with 9- to 16-year follow-up after pregnancy. [Published online ahead of print May 4, 2018]. Diabetes Care. doi:10.2337/dc17-2629.

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