Recent familial analysis showed that rapid renal decline aggregates in diabetic families and is associated with its increased risk among first-degree relatives. While glomerular filtration rate (GFR) trajectories have been studied in several diabetic and non-diabetic cohorts, whether rapid renal decline clusters in diabetic families has not been examined. To determine this, researchers estimated GFR (eGFR) from serum creatinine measurements obtained from 15,612 patients with diabetes at the University of Utah Health Sciences Center and established their renal function trajectories. Patients with rapid renal decline (eGFR slope <-5 ml/min/1.73m2/year) were then mapped to pedigrees using extensive genealogical records from the Utah Population Database to identify high-risk rapid renal decline pedigrees. They identified 2,127 (13.6%) rapid decliners with a median eGFR slope of -8.0 mL/min/1.73m2/year and 51 high-risk pedigrees (ranging in size from 1,450-24,501 members) with excess clustering of rapid renal decline.
Frodsham SG, Yu Z, Lyons AM, et al. The familiality of rapid renal decline in diabetes. [Published online ahead of print November 13, 2018]. Diabetes. doi:10.2337/db18-0838.