Clinical Edge

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Diabetes, Coronary Artery Calcium in Subpopulations

Diab Vasc Dis Res; ePub 2018 Aug 16; Mamudu, et al

There is a need for awareness about subclinical atherosclerosis in patients with diabetes and the effects of coronary artery calcium (CAC) in subpopulations of patients. This according to a recent study that examined the association of cardiovascular disease risk factors with, and their cumulative effect on, CAC in hard-to-reach asymptomatic patients with diabetes. A total of 2,563 community-dwelling asymptomatic subjects from Central Appalachia participated in CAC screening at a heart center. Researchers found:

  • In total, 55.8% and 13.7% of study participants had subclinical atherosclerosis (CAC ≥1) and diabetes, respectively.
  • The presence of CAC was higher in subjects with diabetes (68.5%) than those without (53.8%).
  • Compared to subjects without diabetes with CAC=0, obesity, hypertension, hypercholesterolemia, and smoking increased the odds of the presence of CAC (CAC score 1) regardless of diabetes status; however, with larger odds ratios in subjects with diabetes.
  • Compared to subjects without diabetes with CAC score=0, having 3, 4, and 5 risk factors increased the odds of presence of CAC in subjects with diabetes by 14.06, 32.30, and 47.12 times, respectively.

Citation:

Mamudu HM, Alamian A, Paul T, et al. Diabetes, subclinical atherosclerosis and multiple cardiovascular risk factors in hard-to-reach asymptomatic patients. [Published online ahead of print August 16, 2018]. Diab Vasc Dis Res. doi:10.1177/1479164118791654.

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