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Depression and Severe Dysglycemia Link Evaluated

Diabetes Care; ePub 2017 Dec 18; Gilsanz, Karter, et al

Depression and severe dysglycemia are linked bidirectionally in patients with type 1 diabetes, according to a study involving >3,700 individuals. Participants had type 1 diabetes, as well as depression and severe dysglycemia requiring an ER visit or hospitalization between 1996 and 2015. Investigators looked at how depression impacted severe dysglycemia, and vice versa. Among the results:

  • 41% of patients had depression, 11% hyperglycemia, and 20% hypoglycemia.
  • Patients with depression had >twice the risk of severe hyperglycemia, and an 89% increased risk of severe hypoglycemia.
  • The associations were strongest within the first 6 months of depression diagnosis, >7 times, and >5 times, respectively.
  • They remained strong 1-year post-diagnosis, >5 times, and >4 times, respectively.
  • After severe dysglycemia episodes, hyperglycemic and hypoglycemic events were linked with >twice and 74% increased risk of depression, respectively.


Gilsanz P, Karter A, Schnaider M, Quesenberry C, Whitmer R. The bidirectional association between depression and severe hypoglycemic and hyperglycemic events in type 1 diabetes. [Published online ahead of print December 18, 2017]. Diabetes Care. doi:10.2337/dc17-1566.