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Comorbid Autoimmune Disease and Type 1 Diabetes

J Diabetes; ePub 2018 Sep 18; Bao, Weide, et al

Additional autoimmunity represents a significant comorbidity in patients with type 1 diabetes (T1D), a recent study found. Therefore, clinicians treating patients with T1D should be aware of the risk factors for additional autoimmune diseases. Study population data was gathered from the HealthFacts, a de‐identified patient database from electronic medical records systems in the US. Patients with an International Classification of Diseases diagnosis code specifying type 1 diabetes were included, and patients with a diagnosis of T2D mellitus were excluded. Researchers found:

  • The cross‐sectional study cohort comprised 158,865 adults with T1D, mean age 51.4 ± 18.9 years and 52.5% female.
  • The most common autoimmune diseases were thyroid disease (20.1%), systemic rheumatic diseases (3.4%), rheumatoid arthritis specifically (2.0%), and gastrointestinal autoimmune diseases (1.4%).
  • Most of the autoimmune diseases were more common in women.
  • Caucasians were more likely than other ethnicities to have an additional autoimmune disease.
  • Autoimmune disease prevalence increased with increasing age, significantly in women, such that 38.5% of women aged >80 years had an additional autoimmune disease, relative to 17.9% of women aged ≤29 years.

Citation:

Bao YK, Weide LG, Ganesan VC, et al. High prevalence of comorbid autoimmune diseases in adults with type 1 diabetes from the HealthFacts Database. [Published online ahead of print September 18, 2018]. J Diabetes. doi:10.1111/1753-0407.12856.

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