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BMI a Risk Factor for T2D Regardless of HDP History

Diabetes Care; ePub 2018 Nov 19; Timpka, et al

Maintaining a healthy weight may be of even greater importance in women with a history of hypertensive disorders of pregnancy (HDP), compared with other women with a history of only normotensive pregnancies, to reduce midlife risk of type 2 diabetes (T2D). This according to a recent study that examined to what extent body mass index (BMI) after pregnancy adds to the elevated risk of post-pregnancy T2D in women with a history of HDP. Researchers used data from the Nurses’ Health Study II, a prospective cohort study. In women aged 45–54 years without prior gestational diabetes mellitus, they investigated the interaction between BMI and HDP history on the risk of T2D. For clinical and public health relevance, they focused on additive interaction. They found:

  • In total, 6,563 (11.7%) of 56,159 participants had a history of HDP and 1,341 women developed T2D during 436,333 person-years.
  • BMI was a strong risk factor for T2D regardless of HDP history.
  • However, there was evidence of an additive interaction between BMI and HDP for the risk of T2D.

Timpka S, Stuart JJ, Tanz LJ, Hu FB, Franks PW, Rich-Edwards JW. Postpregnancy BMI in the progression from hypertensive disorders of pregnancy to type 2 diabetes. [Published online ahead of print November 19, 2018]. Diabetes Care. doi:10.2337/dc18-1532.