Clinical Edge

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A1C and Foot Ulcer Healing: No Meaningful Link

Diabetes Care; ePub 2018 April 6; Fesseha, et al

There does not appear to be a clinically meaningful association between baseline or prospective A1C and wound healing in patients with diabetic foot ulcers (DFUs), a recent study found. Researchers conducted a retrospective analysis of an ongoing prospective, clinic-based study of patients with DFUs treated at an academic institution during a 4.7-year period. Data from 270 participants and 584 wounds were included in the analysis. They found:

  • Baseline A1C was not associated with wound healing in univariate or fully adjusted models.
  • Compared with a nadir A1C change from baseline of −0.29 to 0.0 (tertile 2), a nadir A1C change of 0.09 to 2.4 (tertile 3) was positively associated with long-term wound healing in the subset of participants with baseline A1C <7.5%, but no association with wound healing was seen with the mean A1C change from baseline in this group.
  • Neither nadir A1C change nor mean A1C change were associated with long-term wound healing in participants with baseline A1C ≥7.5%.
Citation:

Fesseha BK, Abularrage CJ, Hines KF, et al. Association of hemoglobin A1c and wound healing in diabetic foot ulcers. [Published online ahead of print April 16, 2018]. Diabetes Care. doi:10.2337/dc17-1683.

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