Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Severe COVID-19 illness most often affects children with comorbidities

Key clinical point: Although significant comorbidities do increase risk, severe illness in COVID-19-positive children occurs far less frequently than in adults.

Major finding: Of the 48 children admitted to pediatric ICUs, 40 (83%) had one or more significant preexisting comorbidity.

Study details: A multicenter cross-sectional study of COVID-19-positive children who were admitted to 46 North American participating PICUs during March 14–April 3.

Disclosures: One doctor reported receiving grants from the Health Resources Services Administration. No other relevant financial disclosures were reported.


Shekerdemian LS et al. JAMA Pediatr. 2020 May 11. doi: 10.1001/jamapediatrics.2020.1948.