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Vascular dementia risk particularly high in type 2 diabetes

Key clinical point: A 35% higher risk for vascular dementia was seen in people with type 2 diabetes versus those without; other dementia types were increased or reduced more modestly. Hyperglycemia was associated with a higher risk for vascular and nonvascular subtypes.

Major finding: Comparing diabetic and nondiabetic individuals, the hazard ratios for having vascular dementia was 1.35, nonvascular dementia was 1.08, and Alzheimer’s disease–associated dementia was 0.92.

Study details: Data on 378,299 individuals with type 2 diabetes and 1,886,022 age- and gender-matched controls from the Swedish National Diabetes Register, with 7 years’ follow-up.

Disclosures: The study was financed by the Swedish state under the agreement between the government and the county councils, the ALF agreement, as well as grant from the Novo Nordisk Foundation and the Swedish Association of Local Authorities and Regions. The investigators declared having no conflicts of interest.


Celis-Morales C et al. EASD 2020, Oral presentation 06.