Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Increased cardiovascular risk seen early on with testosterone replacement therapy

Key clinical point: Testosterone replacement therapy may increase the risk of stroke or myocardial infarction.

Major finding: Individuals taking testosterone replacement therapy have a 21% higher risk of stroke, transient ischemic attack, or myocardial infarction.

Study details: A cohort study in 15,401 men with low testosterone levels.

Disclosures: The study was supported by the Canadian Institutes of Health Research. No conflicts of interest were reported.


Loo S et al. Am J Med. 2019 Apr 3. doi: 10.1016/j.amjmed.2019.03.022.