Clinical Edge

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Kratom: Botanical with opiate-like effects increasingly blamed for liver injury

Key clinical point: Kratom, a botanical product with opioid-like activity, is increasingly responsible for cases of liver injury in the United States.

Major finding: In 2018, there were five cases of liver injury associated with products containing kratom (Mitragyna speciose), compared with one case in 2016.

Study details: A post hoc analysis of 404 cases of herbal and dietary supplement-associated liver injury from the Drug Induced Liver Injury Network prospective study.

Disclosures: The investigators disclosed relationships with Gilead, Bristol-Myers Squibb, Sanofi, and others.


Navarro VJ et al. The Liver Meeting 2019, Abstract 212.