Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Prurigo Nodularis Linked with Systemic Conditions

J Am Acad Dermatol; ePub 2018 May 4; Boozalis, et al

Prurigo nodularis (PN), a pruritic dermatosis that itches intensely and can reduce quality of life, disproportionately affects African Americans and is associated with several systemic conditions including HIV, chronic kidney disease, and diabetes, according to a recent study. Researchers conducted a cross-sectional study of patients aged ≥18 years seen at the Johns Hopkins Health System (JHHS) between December 6, 2012, and December 6, 2017. They found:

  • Over the last 5 years, 909 patients with PN were seen at JHHS.
  • African American patients were 3.4 times more likely to have PN than white patients.
  • PN was significantly associated with a variety of systemic, cardiovascular, and psychiatric comorbidities when compared to race-matched controls, including chronic kidney disease, chronic hepatitis C, chronic obstructive pulmonary disease, congestive heart failure, depression, and atopic dermatitis.
  • Black patients with PN were 10.5 times more likely to have HIV than race-matched controls with atopic dermatitis, and 8 times more likely to have HIV than African American patients with psoriasis.
Citation:

Boozalis E, Tang O, Patel S, et al. Ethnic differences and comorbidities of 909 prurigo nodularis patients. [Published online ahead of print May 4, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2018.04.047.

This Week's Must Reads

Timing and Number of cSCCs in Transplant Recipients, JAMA Dermatology; ePub 2018 May 16; Puza, et al

Therapeutic Choices for Psoriasis and Mental Health, J Dermatolog Treat; ePub 2018 May 14; Salame, et al

Rare, Severe Mucocutaneous Reaction Investigated, J Invest Dermatol; ePub 2018 May 11; Micheletti, et al

Skin Manifestations in Graft-Versus-Host-Disease, J Am Acad Dermatol; 2018 Jun; Kim, Schmelkin, et al

Increased Risk of Skin Cancer Found in the Military, J Am Acad Dermatol; 2018 Jun; Riemenschneider, et al

Must Reads in Rare Diseases

Rare, Severe Mucocutaneous Reaction Investigated, J Invest Dermatol; ePub 2018 May 11; Micheletti, et al

Prurigo Nodularis Linked with Systemic Conditions, J Am Acad Dermatol; ePub 2018 May 4; Boozalis, et al

ADPA, Rare Cutaneous Malignancy, Is Increasing, Dermatolog Surg; ePub 2018 Mar 23; Rismiller, et al

Epidemiology of Specific Rare Tumors in US Cohort, J Am Acad Dermatol; 2018 Mar; Mirza, et al

Resilience Levels Examined in Patients with HS, JAMA Dermatol; ePub 2017 Nov 8; Kirby, et al