Prurigo nodularis (PN), a pruritic dermatosis that itches intensely and can reduce quality of life, disproportionately affects African Americans and is associated with several systemic conditions including HIV, chronic kidney disease, and diabetes, according to a recent study. Researchers conducted a cross-sectional study of patients aged ≥18 years seen at the Johns Hopkins Health System (JHHS) between December 6, 2012, and December 6, 2017. They found:
- Over the last 5 years, 909 patients with PN were seen at JHHS.
- African American patients were 3.4 times more likely to have PN than white patients.
- PN was significantly associated with a variety of systemic, cardiovascular, and psychiatric comorbidities when compared to race-matched controls, including chronic kidney disease, chronic hepatitis C, chronic obstructive pulmonary disease, congestive heart failure, depression, and atopic dermatitis.
- Black patients with PN were 10.5 times more likely to have HIV than race-matched controls with atopic dermatitis, and 8 times more likely to have HIV than African American patients with psoriasis.
Boozalis E, Tang O, Patel S, et al. Ethnic differences and comorbidities of 909 prurigo nodularis patients. [Published online ahead of print May 4, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2018.04.047.
This Week's Must Reads
Dermatologist-Delivered Intervention Is Effective, JAMA Dermatology; ePub 2018 Aug 8; Mallett, et al
HRQOL in Patients with Cutaneous T-Cell Lymphoma, Int J Dermatol; ePub 2018 Aug 3; Holahan, Farah, et al
Disparities Seen in Access to Injectable Biologics , J Dermatolog Treat; ePub 2018 Aug 4; Feng, et al
Psoriasis Not Associated with Higher Dementia Risk, J Am Acad Dermatol; ePub 2018 Aug 6; Pezzolo, et al
Discerning Merkel Cell Carcinoma from Other Tumors, Am J Dermapathol; ePub 2018 Jul 24; Bandino, et al
Must Reads in Rare Diseases
Pyoderma Gangrenosum and Underlying Diseases, Am J Clin Dermatol; 2018 Aug; Kridin, Cohen, et al
Mohs Surgery Effective for Atypical Fibroxanthoma, J Am Acad Dermatol; ePub 2018 Jul 5; Tolkachjov, et al
FDA Approves Rituxan for Pemphigus Vulgaris, Genentech Web site; 2018 Jun 7
Climate, Pollution, and Pemphigus Associated, Clin Exp Dermatol; ePub 2018 Jun 1; Ren, et al
Klippel-Trenaunay Syndrome and Quality of Life, J Am Acad Dermatol; ePub 2018 Jun 5; Harvey, et al