Pain and psychiatric conditions, particularly depression and anxiety, are common in patients with Klippel-Trenaunay Syndrome (KTS), according to a recent study. Therefore, awareness of the psychosocial impact and appropriate screening are important for patients with KTS, a rare, congenital, vascular disorder by the triad of capillary malformation (CM), venous malformation (VM) +/- lymphatic malformation, and limb overgrowth. A retrospective review of 410 patients with KTS evaluated between 1976 and 2012 was conducted to identify the presence of pain, psychiatric comorbidities, and psychosocial stressors. Researchers found:
- Pain was reported by 260 patients (63.4%) and was associated with any KTS complication and VMs of the lower extremities and feet.
- 95 patients had a diagnosed psychiatric condition (23.2%), most commonly depression (15.1%) and anxiety (5.1%).
- Pain, superficial thrombosis, deep embolic/thrombotic events, gastrointestinal complications, genitourinary complications, and CM of the hands were associated with having a psychiatric diagnosis.
Harvey JA, Nguyen H, Anderson KR, et al. Pain, psychiatric comorbidities, and psychosocial stressors associated with Klippel-Trenaunay Syndrome. [Published online ahead of print June 5, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2018.05.1245.
This Week's Must Reads
Disease Burden of Atopic Dermatitis in the US, J Invest Dermatol; ePub 2018 Oct 30; Chiesa Fuxench, et al
Psoriasis Associated with Sexual Dysfunction, JAMA Dermatol; ePub 2018 Oct 10; Molina-Leyva, et al
Association Between Psoriasis and Suicide Examined, Dermatolog Ther; ePub 2018 Oct 12; Liang, et al
Study: More Than 85% of Surgeons Use Skin Hooks, Dermatolog Surg; ePub 2018 Oct 9; Clark, et al
FDA Approves Hyrimoz for Plaque Psoriasis, Sandoz news release; 2018 Oct 31
Must Reads in Rare Diseases
Prevalence of Acne Vulgaris Among Patients with HS, J Am Acad Dermatol; ePub 2018 Oct 1; Wertenteil, et al
Pemphigoid Autoimmune Disorder Rare in US, J Am Acad Dermatol; ePub 2018 Aug 27; Wertenteil, et al
Pyoderma Gangrenosum and Underlying Diseases, Am J Clin Dermatol; 2018 Aug; Kridin, Cohen, et al
Mohs Surgery Effective for Atypical Fibroxanthoma, J Am Acad Dermatol; ePub 2018 Jul 5; Tolkachjov, et al
FDA Approves Rituxan for Pemphigus Vulgaris, Genentech Web site; 2018 Jun 7