Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Klippel-Trenaunay Syndrome and Quality of Life

J Am Acad Dermatol; ePub 2018 Jun 5; Harvey, et al

Pain and psychiatric conditions, particularly depression and anxiety, are common in patients with Klippel-Trenaunay Syndrome (KTS), according to a recent study. Therefore, awareness of the psychosocial impact and appropriate screening are important for patients with KTS, a rare, congenital, vascular disorder by the triad of capillary malformation (CM), venous malformation (VM) +/- lymphatic malformation, and limb overgrowth. A retrospective review of 410 patients with KTS evaluated between 1976 and 2012 was conducted to identify the presence of pain, psychiatric comorbidities, and psychosocial stressors. Researchers found:

  • Pain was reported by 260 patients (63.4%) and was associated with any KTS complication and VMs of the lower extremities and feet.
  • 95 patients had a diagnosed psychiatric condition (23.2%), most commonly depression (15.1%) and anxiety (5.1%).
  • Pain, superficial thrombosis, deep embolic/thrombotic events, gastrointestinal complications, genitourinary complications, and CM of the hands were associated with having a psychiatric diagnosis.

Citation:

Harvey JA, Nguyen H, Anderson KR, et al. Pain, psychiatric comorbidities, and psychosocial stressors associated with Klippel-Trenaunay Syndrome. [Published online ahead of print June 5, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2018.05.1245.

This Week's Must Reads

Should Medical Coding Be Taught During Residency?, J Drugs Dermatol; 2018 Jun; Blecher, Halverstam, et al

Primary Closure Lengths in MMS Based on Cancer Type, Dermatolog Surg; ePub 2018 Jun 8; Theroux, et al

Citizen Pscientist: Important New Research Tool, Dermatol Ther (Heidelb); ePub 2018 Jun 6; Sanchez, et al

Acne Successfully Treated with Laser Combination, Dermatolog Surg; ePub 2018 Jun 5; Bakus, et al

FDA Approves Rituxan for Pemphigus Vulgaris, Genentech Web site; 2018 Jun 7

Must Reads in Rare Diseases

FDA Approves Rituxan for Pemphigus Vulgaris, Genentech Web site; 2018 Jun 7

Climate, Pollution, and Pemphigus Associated, Clin Exp Dermatol; ePub 2018 Jun 1; Ren, et al

Klippel-Trenaunay Syndrome and Quality of Life, J Am Acad Dermatol; ePub 2018 Jun 5; Harvey, et al

Rare, Severe Mucocutaneous Reaction Investigated, J Invest Dermatol; ePub 2018 May 11; Micheletti, et al

Prurigo Nodularis Linked with Systemic Conditions, J Am Acad Dermatol; ePub 2018 May 4; Boozalis, et al