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Climate, Pollution, and Pemphigus Associated

Clin Exp Dermatol; ePub 2018 Jun 1; Ren, et al

Increasing temperature, UV exposure, and small particle air pollution are associated with increased hospitalization for pemphigus, according to a recent study. Therefore, patients with pemphigus may benefit from avoidance of these potential environmental triggers. The analysis used data from the 2002-2012 National Inpatient Sample, including 68,476,920 children and adults, and measurements of relative humidity (%), UV index, outdoor air temperature, and particulate matter of ≤ 2.5 or ≤ 10 μm (PM2.5 and PM10). Researchers found:

  • Higher rates of admission primarily for pemphigus occurred during the summer and autumn months (June-November), with the highest admission rates in July and October (both 19.7 per million).
  • There was significant statewide variation of the prevalence of hospitalization for pemphigus, with apparent hotspots located in the southwest and northeast states.
  • Hospitalization for a primary diagnosis of pemphigus vs other diagnosis was associated with significantly lower humidity, analysis of variance, and higher temperature, UV index, PM2.5, and PM10.
  • All associations remained significant in multilevel regression models that controlled for age, sex and race/ethnicity, except for ultraviolet index, which was associated with pemphigus hospitalization only for Hispanic patients.

Citation:

Ren Z, Hsu D, Brieva J, Silverberg JI. Association between climate, pollution and hospitalization for pemphigus in the USA. [Published online ahead of print June 1, 2018]. Clin Exp Dermatol. doi:10.1111/ced.13650.

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