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Vascular Inflammation, CAD Indices, and Psoriasis

JAMA Cardiology; ePub 2018 Sep 12; Joshi, et al

Aortic vascular inflammation (VI) is associated with broad coronary artery disease (CAD) indices, suggesting that aortic VI may be a surrogate for early CAD in patients with psoriasis. This according to a recent study that aimed to assess the association between aortic VI and CAD indices, including total plaque burden (TB), non-calcified coronary plaque burden (NCB), luminal stenosis, and high-risk plaques (HRP) prevalence, in psoriasis. In a cross-sectional cohort study at the National Institutes of Health, 215 consecutive patients with psoriasis were recruited. All patients underwent 18F-FDG PET/CT for aortic VI assessment, and 190 of 215 patients underwent coronary computed tomography angiography to characterize CAD. Researchers found:

  • Among total patients with psoriasis (mean [SD] age, 50.4 [12.6] years; 126 men [59%]), patients with increased aortic VI had increased TB, and higher prevalence of luminal stenosis and HRP.
  • The aortic VI and TB association was primarily driven by NCB, whereas the aortic VI and HRP association was driven by low-attenuation plaque.
  • All associations of aortic VI remained significant after adjustment for cardiovascular risk factors: aortic VI and TB, NCB, luminal stenosis, and HRP.

Citation:

Joshi AA, Lerman JB, Dey AK, et al. Association between aortic vascular inflammation and coronary artery plaque characteristics in psoriasis. [Published online ahead of print September 12, 2018]. JAMA Cardiology. doi:10.1001/jamacardio.2018.2769.

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