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Psoriasis Not Associated with Higher Dementia Risk

J Am Acad Dermatol; ePub 2018 Aug 6; Pezzolo, et al

Psoriasis was not associated with preclinical markers or higher dementia risk, according to a recent population-based study. Researchers identified 318 psoriatic and 9,678 non-psoriatic participants (mean age: 66.1 years, 58% women). The association of psoriasis with cognitive function, mild cognitive impairment (MCI) and MRI-markers of brain damage was examined by linear and logistic regression. Dementia risk was calculated using Cox regression. Models were adjusted for age, gender, education and cardio-vascular risk factors. They found:

  • Cognitive test scores and volumetric, microstructural, focal measures on brain MRI did not differ between psoriasis (28% systemic/ultraviolet treatment) and non-psoriasis participants and psoriasis was not associated with MCI (adjusted OR 0.87).
  • During 115,000 person-years of follow-up, 810 incident dementia cases (15 among psoriasis patients) occurred.
  • After adjusting for confounders, psoriasis was associated with a lower risk of developing dementia (adjusted HR 0.50).


Pezzolo E, Mutlu U, Vernooij MW, et al. Psoriasis is not associated with cognition, brain imaging markers and risk of dementia: The Rotterdam Study. [Published online ahead of print August 6, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2018.07.046.

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