Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Psoriasis Linked with Increased Herpes Zoster Risk

PLoS One; ePub 2017 Aug 22; Tsai, et al

Psoriasis is associated with an increased risk of herpes zoster (HZ), which involves differences in sex and age, according to a recent study. Researchers conducted a population-based retrospective cohort study consisting of 4,077 patients with newly diagnosed psoriasis between 2000 and 2006. Each patient with psoriasis was frequency-matched with 4 people without psoriasis, by sex, age, and index year. (non-psoriasis cohort: n=16,308). They found:

  • The overall incidence density rate of HZ in the psoriasis cohort was greater than in the non-psoriasis cohort (4.50 vs 3.44 per 1,000 person-years), with a multivariable Cox proportional hazards model measured adjusted hazard ratio (HR) of 1.29.
  • In addition, compared with the non-psoriasis cohort, the risk of HZ was higher in the severe psoriasis cohort than in the non-psoriasis cohort (adjusted HR, 1.61).
  • The comparison between psoriasis and non-psoriasis cohorts revealed a greatest magnitude risk of HZ in women (adjusted HR, 1.36), study participants in the age group of 20–39 years (adjusted HR, 1.77), and study participants without any comorbidities (adjusted HR, 1.37).


Tsai S-Y, Chen H-J, Lio C-F, et al. Increased risk of herpes zoster in patients with psoriasis: A population-based retrospective cohort study. [Published online ahead of print August 22, 2017]. PLoS One. doi:10.1371/journal.pone.0179447.

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