There is an association of psoriasis with nonalcoholic fatty liver disease (NAFLD), according to a recent study, and findings also suggest an increased presence of metabolic syndrome components in patients with psoriasis and NAFLD. In an observational, case-control study at an outpatient dermatology clinic of the George Washington Medical Faculty Associates in Washington, DC, researchers recruited 151 adult patients with psoriasis and 51 control subjects. NAFLD was diagnosed by ultrasonography after excluding secondary causes of liver disease. Regression analysis was used to assess the associations between: 1) NAFLD and psoriasis and 2) metabolic syndrome components and NAFLD among psoriasis patients. They found:
- NAFLD was more prevalent in patients with psoriasis (21.2% vs 7.8%).
- However, psoriasis was not associated with NAFLD when matching for age, sex, and body mass index (BMI) (odds ratio: 2.63).
- As compared to patients with psoriasis but without NAFLD, those with NAFLD were more likely to have obesity (BMI: 34.9 vs 27.2 vs 25.9–28.5).
- NAFLD in patients with psoriasis was also associated with select components of metabolic syndrome, including hyperglycemia and hyperlipidemia.
Awosika O, Eleryan MG. Rengifo-Pardo M, Doherty L, Martin LW, Ehrlich A. A case-control study to evaluate the prevalence of nonalcoholic fatty liver disease among patients with moderate-to-severe psoriasis. J Clin Aesthet Dermatol. 2018;11(6):33-37.
This Week's Must Reads
ALT-70 Gets High Marks for Diagnosing Cellulitis, J Am Acad Dermatol; ePub 2018 Jul 9; Li, et al
MMS/MART-1 Immunostaining for Atypical Melanocytes, J Am Acad Dermatol; ePub 2018 Jul 9; Etzkorn, et al
Economic Analysis of Noninvasive Pathologic Assay, JAMA Dermatology; ePub 2018 Jul 11; Hornberger, et al
Use of Advanced Practice Professionals on the Rise, JAMA Dermatology; ePub 2018 Jul 11; Zhang, et al
Folate and Risk of Cutaneous Melanoma in Women, Cancer Epidemiol; 2018 Aug; Dhana, Ten, Li, et al
Must Reads in Mixed Topics
Predicting Disease Activity and Improvement in CLE, J Am Acad Dermatol; ePub 2018 Jul 2; Ker, Teske, et al
FDA Approves Qbrexza for Excessive Armpit Sweating, Dermira Inc. news release; 2018 Jun 29
Pretransplant History, Melanoma Outcomes Examined, Melanoma Res; ePub 2018 Jun 26; Puza, Barbas, et al
Psoriasis, Nonalcoholic Fatty Liver Disease Linked, J Clin Asthet Dermatol; 2018 Jun 1; Awosika, et al
Association Found Between HS and Crohn’s Disease, JAMA Dermatology; ePub 2018 May 23; Garg, et al