Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Prevalence and Type of Genital Lesions in OTRs

JAMA Dermatology; ePub 2018 Jan 31; Nadhan, et al

Genital lesions in organ transplant recipients (OTRs) are common, but awareness is low, according to a recent investigation. To that end, it is recommended that all OTRs undergo thorough inspection of genital skin as a part of routine posttransplant skin examinations. In this retrospective review, researchers found:

  • Of the total 496 OTRs who underwent full skin examination, 376 OTRs were evaluated during period 1 (mean [SD] age, 60 years; 45 [65.2%] male; 164 [43.6%] white) and 120 OTRs were evaluated during period 2 of the study (mean age, 56 years; 76 [63.3%] male; 30 [25.0%] white).
  • Overall, 111 of the 120 OTRs (92.5%) denied the presence of genital lesions during the history-taking portion of the medical examination.
  • Genital lesions were found in 53 OTRs (44.2%), cutaneous malignant tumors (basal cell carcinoma and SCC in situ) in 6 (5.0%), genital SCC in situ in 3 (4.2%), and condyloma in 29 (24.2%).
  • 8 of the 12 SCC in situ lesions (66.7%) were positive for high-risk human papillomavirus (HPV).

Nadhan KS, Larijani M, Abbott J, Doyle AM, Linfante AW, Chung CL. Prevalence and types of genital lesions in organ transplant recipients. [Published online ahead of print January 31, 2018]. JAMA Dermatology. doi:10.1001/jamadermatol.2017.5801.

This Week's Must Reads

Latent TB Prevalent in Patients with Psoriasis, J Dermatolog Treat; 2018 Nov; Lee, Amin, et al

Understanding Scope of Cutaneous Pain in Psoriasis, J Dermatolog Treat; ePub 2018 Sep 26; Pithadia, et al

Ixekizumab Proves Effective in Psoriasis Treatment, J Clin Pharmacol; 2018 Nov; Chigutsa, et al

QOL Impaired in Young Adults with Psoriasis, J Dermatolog Treat; ePub 2018 Sep 7; Bronckers, et al

Vascular Inflammation, CAD Indices, and Psoriasis, JAMA Cardiology; ePub 2018 Sep 12; Joshi, et al

Must Reads in Mixed Topics

Pruritis Strongly Associated with Certain Cancers , J Am Acad Dermatol; ePub 2018 Sep 11; Larson, et al

Sleep Impairment Common in Persons with AD, Dermatitis; ePub 2018 Aug 31; Li, Fishbein, et al

Alopecia Areata Associated with Impaired HRQoL, J Am Acad Dermatol; 2018 Sep; Liu, King, et al

Psoriasis Linked with Crohn’s, Ulcerative Colitis , J Invest Dermatol; ePub 2018 Aug 18; Egeberg, et al

Renal Transplant Rejection Linked with Risk of cSCC, Clin Exp Dermatol; ePub 2018 Jun 27; Puza, et al