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Prevalence and Type of Genital Lesions in OTRs

JAMA Dermatology; ePub 2018 Jan 31; Nadhan, et al

Genital lesions in organ transplant recipients (OTRs) are common, but awareness is low, according to a recent investigation. To that end, it is recommended that all OTRs undergo thorough inspection of genital skin as a part of routine posttransplant skin examinations. In this retrospective review, researchers found:

  • Of the total 496 OTRs who underwent full skin examination, 376 OTRs were evaluated during period 1 (mean [SD] age, 60 years; 45 [65.2%] male; 164 [43.6%] white) and 120 OTRs were evaluated during period 2 of the study (mean age, 56 years; 76 [63.3%] male; 30 [25.0%] white).
  • Overall, 111 of the 120 OTRs (92.5%) denied the presence of genital lesions during the history-taking portion of the medical examination.
  • Genital lesions were found in 53 OTRs (44.2%), cutaneous malignant tumors (basal cell carcinoma and SCC in situ) in 6 (5.0%), genital SCC in situ in 3 (4.2%), and condyloma in 29 (24.2%).
  • 8 of the 12 SCC in situ lesions (66.7%) were positive for high-risk human papillomavirus (HPV).

Nadhan KS, Larijani M, Abbott J, Doyle AM, Linfante AW, Chung CL. Prevalence and types of genital lesions in organ transplant recipients. [Published online ahead of print January 31, 2018]. JAMA Dermatology. doi:10.1001/jamadermatol.2017.5801.

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