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Predicting Disease Activity and Improvement in CLE

J Am Acad Dermatol; ePub 2018 Jul 2; Ker, Teske, et al

Baseline Cutaneous Lupus Erythematosus Disease Area and Severity Index activity (CLASI-A) >9, minority race, and shorter disease duration predict cutaneous lupus erythematosus (CLE) disease activity improvement. This according to a recent study in which researchers characterized and compared the disease course of CLE patients using CLASI. 83 patients with CLASI scores collected from ≥3 study visits within 2 years had disease activity and damage trends calculated by average change scores (ACS). Trends were classified as “improved” (ACS ≤-3), “worsened” (ACS ≥+3), or “stable” (-3< ACS<+3). Linear regression models compared CLASI trends between groups. They found:

  • 72.73% with initial CLASI activity (CLASI-A) >9 (n=33) had improved disease activity vs 14.00% with initial CLASI-A ≤9 (n=50).
  • Linear regression analyses showed significant improvement in CLASI-A scores in patients with baseline CLASI-A >9, baseline CLASI damage (CLASI-D) ≥10, minority races, and CLE disease duration ≤1 year.
  • 35.71% with baseline CLASI-D ≥10 (n=28) had improving disease damage vs 5.26% with initial CLASI-D=5-9 (n=19) and 0% with initial CLASI-D <5 (n=36).

Citation:

Ker KJ, Teske NM, Feng R, Chong BF, Werth VP. Natural history of disease activity and damage in patients with cutaneous lupus erythematosus. [Published online ahead of print July 2, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2018.06.040.

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