Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Similar Survival: Multiple, Single Primary Melanoma

J Am Acad Dermatol; ePub 2018 Feb 27; Grossman, et al

Patients with multiple primary melanomas (MPM) had similar survival time as patients with single primary melanomas (SPM), according to a recent study. Records of 14,138 individuals obtained from the Surveillance, Epidemiology, and End-Results (SEER) registry of all melanomas diagnosed or treated in Utah from 1973-2011 were reviewed. A single matched control patient was selected randomly from the SPM cohort for each MPM patient, with the restriction that they survived at least as long as the interval between the first and second diagnoses for the matched MPM patient. Researchers found:

  • Survival curves (n=887 MPM, 887 SPM) without covariates showed a significant survival disadvantage for MPM patients (chi-squared = 39.29).
  • However, a multivariate Cox proportional hazards model showed no significant survival difference (hazard ratio = 1.07).
  • Restricting the multivariate analysis to invasive melanomas also showed no significant survival difference (hazard ratio = 0.99).
Citation:

Grossman D, Farnham JM, Hyngstrom J, et al. Similar survival of patients with multiple vs. single primary melanomas based on Utah SEER data (1973-2011). [Published online ahead of print February 27, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2018.02.055.

This Week's Must Reads

Should Medical Coding Be Taught During Residency?, J Drugs Dermatol; 2018 Jun; Blecher, Halverstam, et al

Primary Closure Lengths in MMS Based on Cancer Type, Dermatolog Surg; ePub 2018 Jun 8; Theroux, et al

Citizen Pscientist: Important New Research Tool, Dermatol Ther (Heidelb); ePub 2018 Jun 6; Sanchez, et al

Acne Successfully Treated with Laser Combination, Dermatolog Surg; ePub 2018 Jun 5; Bakus, et al

FDA Approves Rituxan for Pemphigus Vulgaris, Genentech Web site; 2018 Jun 7

Must Reads in Melanoma

Gaps in Melanoma Reporting Practices Discovered , Dermatolog Surg; ePub 2018 May 25; Svoboda, et al

Increased Risk of Skin Cancer Found in the Military, J Am Acad Dermatol; 2018 Jun; Riemenschneider, et al

Interest and Uptake of MC1R Test for Melanoma Risk, JAMA Dermatology; ePub 2018 May 9; Hay, et al

Identifying Shiny White Streaks in Melanoma, J Am Acad Dermatol; 2018 May; Verzi, et al

Digital Dermoscopic Image Analyzer Evaluated, J Am Acad Dermatol; 2018 May; del Rosario, et al