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Similar Survival: Multiple, Single Primary Melanoma

J Am Acad Dermatol; ePub 2018 Feb 27; Grossman, et al

Patients with multiple primary melanomas (MPM) had similar survival time as patients with single primary melanomas (SPM), according to a recent study. Records of 14,138 individuals obtained from the Surveillance, Epidemiology, and End-Results (SEER) registry of all melanomas diagnosed or treated in Utah from 1973-2011 were reviewed. A single matched control patient was selected randomly from the SPM cohort for each MPM patient, with the restriction that they survived at least as long as the interval between the first and second diagnoses for the matched MPM patient. Researchers found:

  • Survival curves (n=887 MPM, 887 SPM) without covariates showed a significant survival disadvantage for MPM patients (chi-squared = 39.29).
  • However, a multivariate Cox proportional hazards model showed no significant survival difference (hazard ratio = 1.07).
  • Restricting the multivariate analysis to invasive melanomas also showed no significant survival difference (hazard ratio = 0.99).

Grossman D, Farnham JM, Hyngstrom J, et al. Similar survival of patients with multiple vs. single primary melanomas based on Utah SEER data (1973-2011). [Published online ahead of print February 27, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2018.02.055.

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