Clinical Edge

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Mole-Prone Phenotype in Adolescents Examined

JAMA Dermatol; ePub 2017 Jun 7; Xu, Marchetti, et al

There are clinically recognizable factors associated with a mole-prone phenotype that may facilitate the identification of individuals at risk for melanoma, according to a recent study. A prospective observational cohort study was conducted from January 1, 2009, to December 31, 2014, with a 2- to 3-year follow-up. A total of 569 students enrolled in the 8th or 9th grade (mean [SD] age, 14.4 [0.7] years) were included. The overall retention rate was 73.3%, and 417 students were reassessed in the 11th grade. Researchers found:

  • Of the 417 students assessed at follow-up in the 11th grade (166 females and 251 males), 111 participants (26.6%) demonstrated a mole-prone phenotype: 69 students (62.2%) with 1 nevus greater than 5 mm in diameter, 23 students (20.7%) with total nevus count in the top decile, and 19 students (17.1%) with both characteristics.
  • On multivariate analysis, baseline total nevus count and increased variability of nevus dermoscopic pattern were associated with a mole-prone phenotype.

Citation:

Xu H, Marchetti MA, Dusza SW, et al. Factors in early adolescence associated with a mole-prone phenotype in late adolescence. [Published online ahead of print June 7, 2017]. JAMA Dermatol. doi:10.1001/jamadermatol.2017.1547.

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