Prospective risk of melanoma has decreased substantially in both mutation-positive and mutation-negative families over 4 decades, while melanoma has greatly increased in the general population, a recent study found. Researchers assessed risks of melanoma and other cancers in 1,226 members of 56 families followed for up to 4 decades to population rates in the Surveillance, Epidemiology, and End Results (SEER) program. All families were tested for mutations in CDKN2A and CDK4; 29 were mutation-positive and 27 mutation-negative. They compared rates of invasive melanomas, both first and second, by family mutation status, to SEER. Findings included:
- Comparing 3 calendar periods of the study, risk of first primary melanoma decreased slightly.
- Risks of melanoma after first examination, however, were approximately one-third the risks prior to the first examination, in both mutation-positive and mutation-negative families.
- Among patients with melanoma, risk of a second melanoma was increased 10-fold in all families; risk was somewhat higher in mutation-positive families.
- Risks of other second cancers were increased only for pancreatic cancer after melanoma in mutation-positive families.
Tucker MA, Elder DE, Curry M, et al. Risks of melanoma and other cancers in melanoma-prone families over four decades. [Published online ahead of print February 2, 2018]. J Invest Dermatol. doi:10.1016/j.jid.2018.01.021.
This Week's Must Reads
Psoriasis Linked with Increased All-Cause Mortality, J Am Acad Dermatol; ePub 2018 Dec 24; Dhana, et al
Examining Patient Resistance to Psoriasis Treatment, Exp Opin Pharmacother; ePub 2018 Dec 27; Heath, et al
Psoriasis Linked with Periodontal Inflammation, J Invest Dermatol; ePub 2019 Jan 2; Woeste, et al
Psoriasis Independently Linked with Depression Risk, Br J Dermatol; 2019 Jan; Egeberg, Thyssen, Wu, et al
Health Literacy May Benefit Patients with Psoriasis, Br J Dermatol; ePub 2018 Dec 31; Larsen, et al
Must Reads in Melanoma
Factors Associated with Suspected Skin Cancers , J Am Acad Dermatol; ePub 2018 Dec 10; Beaulieu, et al
High Birth Weight, Early UV Exposure, and Melanoma, Epidemiology; ePub 2018 Nov 29; Wojcik, et al
Head/Neck Melanomas Have High Local Recurrence Risk, J Am Acad Dermatol; ePub 2018 Nov 17; Fix, et al
Early Desmoplastic Melanoma Treatment Comparison, Melanoma Res; ePub 2018 Oct 31; Abbott, et al
Melanoma Risk and Moderately Dysplastic Nevi, JAMA Dermatol; ePub Oct 10; Kim, Berry, et al