Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Melanoma Risk Assessed in Melanoma-Prone Families

J Invest Dermatol; ePub 2018 Feb 2; Tucker, Elder, et al

Prospective risk of melanoma has decreased substantially in both mutation-positive and mutation-negative families over 4 decades, while melanoma has greatly increased in the general population, a recent study found. Researchers assessed risks of melanoma and other cancers in 1,226 members of 56 families followed for up to 4 decades to population rates in the Surveillance, Epidemiology, and End Results (SEER) program. All families were tested for mutations in CDKN2A and CDK4; 29 were mutation-positive and 27 mutation-negative. They compared rates of invasive melanomas, both first and second, by family mutation status, to SEER. Findings included:

  • Comparing 3 calendar periods of the study, risk of first primary melanoma decreased slightly.
  • Risks of melanoma after first examination, however, were approximately one-third the risks prior to the first examination, in both mutation-positive and mutation-negative families.
  • Among patients with melanoma, risk of a second melanoma was increased 10-fold in all families; risk was somewhat higher in mutation-positive families.
  • Risks of other second cancers were increased only for pancreatic cancer after melanoma in mutation-positive families.

Tucker MA, Elder DE, Curry M, et al. Risks of melanoma and other cancers in melanoma-prone families over four decades. [Published online ahead of print February 2, 2018]. J Invest Dermatol. doi:10.1016/j.jid.2018.01.021.

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