Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Melanoma Risk Assessed in Melanoma-Prone Families

J Invest Dermatol; ePub 2018 Feb 2; Tucker, Elder, et al

Prospective risk of melanoma has decreased substantially in both mutation-positive and mutation-negative families over 4 decades, while melanoma has greatly increased in the general population, a recent study found. Researchers assessed risks of melanoma and other cancers in 1,226 members of 56 families followed for up to 4 decades to population rates in the Surveillance, Epidemiology, and End Results (SEER) program. All families were tested for mutations in CDKN2A and CDK4; 29 were mutation-positive and 27 mutation-negative. They compared rates of invasive melanomas, both first and second, by family mutation status, to SEER. Findings included:

  • Comparing 3 calendar periods of the study, risk of first primary melanoma decreased slightly.
  • Risks of melanoma after first examination, however, were approximately one-third the risks prior to the first examination, in both mutation-positive and mutation-negative families.
  • Among patients with melanoma, risk of a second melanoma was increased 10-fold in all families; risk was somewhat higher in mutation-positive families.
  • Risks of other second cancers were increased only for pancreatic cancer after melanoma in mutation-positive families.

Tucker MA, Elder DE, Curry M, et al. Risks of melanoma and other cancers in melanoma-prone families over four decades. [Published online ahead of print February 2, 2018]. J Invest Dermatol. doi:10.1016/j.jid.2018.01.021.

This Week's Must Reads

Psoriasis Linked with Increased All-Cause Mortality, J Am Acad Dermatol; ePub 2018 Dec 24; Dhana, et al

Examining Patient Resistance to Psoriasis Treatment, Exp Opin Pharmacother; ePub 2018 Dec 27; Heath, et al

Psoriasis Linked with Periodontal Inflammation, J Invest Dermatol; ePub 2019 Jan 2; Woeste, et al

Psoriasis Independently Linked with Depression Risk, Br J Dermatol; 2019 Jan; Egeberg, Thyssen, Wu, et al

Health Literacy May Benefit Patients with Psoriasis, Br J Dermatol; ePub 2018 Dec 31; Larsen, et al

Must Reads in Melanoma

Factors Associated with Suspected Skin Cancers , J Am Acad Dermatol; ePub 2018 Dec 10; Beaulieu, et al

High Birth Weight, Early UV Exposure, and Melanoma, Epidemiology; ePub 2018 Nov 29; Wojcik, et al

Head/Neck Melanomas Have High Local Recurrence Risk, J Am Acad Dermatol; ePub 2018 Nov 17; Fix, et al

Early Desmoplastic Melanoma Treatment Comparison, Melanoma Res; ePub 2018 Oct 31; Abbott, et al

Melanoma Risk and Moderately Dysplastic Nevi, JAMA Dermatol; ePub Oct 10; Kim, Berry, et al