Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Interest and Uptake of MC1R Test for Melanoma Risk

JAMA Dermatology; ePub 2018 May 9; Hay, et al

There were moderately high levels of interest and uptake in the MC1R genetic test for melanoma risk in a recent randomized clinical trial that examined a diverse primary care population sample from University of New Mexico General Internal Medicine clinics. Study participants were randomized to either a usual-care condition (National Cancer Institute skin cancer pamphlet for diverse skin types) or an MC1R test offer. Of the 600 participants recruited to the overall trial, the present study included those 499 participants randomized to the MC1R test offer. Investigators found:

  • Of total participants (220 [44%] non-Hispanic white, 242 [48%] Hispanic, 396 [79%] female; mean [SD] age, 54 [14.3] years), 232 (46%) elected to learn about MC1R testing by logging onto the website; 204 (88%) of those who logged on decided to request testing; and 167 (82%) of those who requested testing returned the kit.
  • The strongest predictors of website log on were race/ethnicity and education (non-Hispanic whites were more likely to log on, as were more highly educated individuals).
  • The strongest predictor of ordering the test was sunburn history.


Hay JL, Zielaskowski K, White KM, et al. Interest and uptake of MC1R testing for melanoma risk in a diverse primary care population. A randomized clinical trial. [Published online ahead of print May 9, 2018]. JAMA Dermatology. doi:10.1001/jamadermatol.2018.0592.

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