The ALT-70 predictive model for lower extremity cellulitis and thermal imaging outperformed thermal imaging in diagnosing lower extremity cellulitis, according to results of a recent evaluation. Furthermore, the accuracy of the ALT-70 was high and consistent with previously published reports. Broad implementation of ALT-70 into clinical practice may decrease misdiagnosis rates of lower extremity cellulitis. Researchers collected ALT-70 and thermal imaging data from patients with presumed lower extremity cellulitis and compared classification measures and accuracy for ALT-70, thermal imaging, and combination testing (ALT-70 plus thermal imaging). 67 patients with ALT-70 and thermal imaging data were enrolled. They found:
- ALT-70 conferred the highest sensitivity (97.8%) and negative predictive value (90.9%), while combination testing had the highest specificity (71.4%) and positive predictive value (86.6%).
- ALT-70 had improved classification measures compared to thermal imaging.
- Combination testing conferred a marginal benefit to ALT-70 alone.
Li DG, Dewan AK, Xia FD, Khosravi H, Joyce C, Mostaghimi A. The ALT-70 predictive model outperforms thermal imaging for the diagnosis of lower extremity cellulitis: A prospective evaluation. [Published online ahead of print July 9, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2018.06.062.
This Week's Must Reads
Latent TB Prevalent in Patients with Psoriasis, J Dermatolog Treat; 2018 Nov; Lee, Amin, et al
Understanding Scope of Cutaneous Pain in Psoriasis, J Dermatolog Treat; ePub 2018 Sep 26; Pithadia, et al
Ixekizumab Proves Effective in Psoriasis Treatment, J Clin Pharmacol; 2018 Nov; Chigutsa, et al
QOL Impaired in Young Adults with Psoriasis, J Dermatolog Treat; ePub 2018 Sep 7; Bronckers, et al
Vascular Inflammation, CAD Indices, and Psoriasis, JAMA Cardiology; ePub 2018 Sep 12; Joshi, et al
Must Reads in Dermatopathology
Sentinel Lymph Node Positivity Markers in Melanoma, J Am Acad Dermatol; ePub 2018 Sep 18; Conic, et al
Recurrent Morphological Patterns in Melanomas, J Am Acad Dermatol; ePub Aug 27; Klebanov, et al
Evaluation of Combined Detection Method for BCC, JAMA Dermatology; ePub 2018 Aug 22; Sahu, et al
Pathology Methods for Melanocytic Lesions Compared, JAMA Dermatology; ePub 2018 Aug 15; Onega, et al
High Quantity of False Negatives Found in Biopsies, J Drugs Dermatol; 2018 Jul; Zakhem, Terushkin, et al