Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Two Surgeries Effective for Merkel Cell Carcinoma

J Am Acad Dermatol; ePub 2018 Feb 3; Singh, et al

Mohs micrographic surgery (MOHS) appears to be as effective as wide local excision (WLE) in treating early stage Merkel cell carcinoma (MCC), a recent study found. Researchers performed a retrospective review of all cases in the National Cancer Data Base (NCDB) of clinical Stage I-II MCC treated with WLE or MOHS. They found:

  • 1,795 cases of Stage I-II MCC were identified who underwent WLE (n=1,685) or MOHS (n=110).
  • There was no difference in residual tumor on surgical margins between the 2 treatment groups.
  • On multivariate analysis, there was no difference in overall survival between the treatment modalities.
  • There was no difference in overall survival between the 2 groups on propensity score matched analysis.


Singh B, Qureshi M, Truong MT, Sahni D. Demographics and outcomes of stage I-II Merkel cell carcinoma treated with Mohs micrographic surgery compared with wide local excision in the National Cancer Data Base. [Published online ahead of print February 3, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2018.01.041.

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