Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Mohs Surgery Effective for Invasive Melanomas

Dermatolog Surg; ePub 2018 Sep 7; Degesys, et al

Mohs micrographic surgery is an effective treatment method for invasive melanoma, as evidenced by low recurrence rates and high rates of disease-free survival, according to a recent study. A retrospective cohort study evaluated 123 melanomas excised using Mohs micrographic surgery (MMS) with MART-1 immunostain. Local recurrence, metastasis, overall survival, and disease-free survival rates were calculated. These were compared with historical controls. Among included patients, 78 were men (63%) and 45 were women (37%), with a mean age of 66.48 years. They found:

  • Mean follow-up time was 1,273 days (3.49 years).
  • Local recurrence was identified in 2/123 (1.63%) lesions.
  • Local recurrence was identified in 1/70 (1.43%) of head and neck cases.
  • Tumor location was head and neck in 70 lesions (56.9%).
  • Overall survival was 95.12% and disease-specific survival was 100%.


Degesys CA, Powell HB, Hsia L-L B, Merritt BG. Outcomes for invasive melanomas treated with Mohs micrographic surgery: A retrospective cohort study. [Published online ahead of print September 7, 2018]. Dermatolog Surg. doi:10.1097/DSS.0000000000001658.

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