Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

ADPA, Rare Cutaneous Malignancy, Is Increasing

Dermatolog Surg; ePub 2018 Mar 23; Rismiller, et al

Aggressive digital papillary adenocarcinoma (ADPA) is a rare malignancy with increasing incidence, according to a recent study. Identification of patients best suited for additional diagnostic procedures or more extensive surgical resection remains challenging, however. Data from 18 registries within the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program were examined for patients with ADPA (1995–2013) to provide demographic- and cancer-related information, and to calculate race- and age-specific rate ratios, incidence, and mortality. Patients were stratified by the stage for further comparison. Researchers found:

  • 94 cases of ADPA were identified.
  • Overall, ADPA incidence was 0.08 per 1,000,000 person-years, 4 times higher in males than in females (0.13 vs 0.03), and most common in Caucasians.
  • Regional disease spread occurred in 22.3% of patients and disease-specific mortality in 2.1% of patients.
  • Patients with regional vs localized disease at diagnosis did not differ significantly in sex, age, race, primary site, tumor size, or mortality.

Rismiller K, Knackstedt TJ. Aggressive digital papillary adenocarcinoma: Population-based analysis of incidence, demographics, treatment, and outcomes. [Published online ahead of print March 23, 2018]. Dermatolog Surg. doi:10.1097/DSS.0000000000001483.

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